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KMID : 0367220000170020157
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Sejong Medical Journal
2000 Volume.17 No. 2 p.157 ~ p.167
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Endothelium-dependent vasodilation in smokers and acute effect of ascorbic acid
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최락경/Choi, Rak-Kyeong
고충원/임달수/황흥곤/Goh, Choong-Won/Lim, Dal-Soo/Hwang, Hweung-Kon
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Abstract
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Chronic smoking is associated with endothelial dysfunction, an early stage of atherosclerosis. Recent studies have indicated that ascorbic add improves endothelium-dependent vasomotor dysfunction in chronic smokers and coronary artery disease. intracoronary studies(intra-arterial infusion of ascorbic acid) have served as gold standard for endothelial function testing for the lag´, decade.
The purtx)se of this study was to assess the acute effect of supplementation with oral vitamin C on endothelial dysfunction with noninvasive methods in chronic smokers.
We measured brachial artery dimension and blood flow in 9 chronic smokers and 12 nonsmokers before and after supplementation with oral 2g ascorbic acid.
Brachial artery dilation ´in response to hyperemia was assessed by high resolution vascular ultrasound. Before supplementation with ascorbic acid, smokers had impaired flowmediated dilation(FMD), as compared with nonsmokers (8.7 ±1.2 vs. 10.7±1.9%, p=0.027). In smokers, supplementation with ascorbic acid restored flow-mediated dlation(10.4±22 vs. 13.7 ±2.3%, p=0.003), whereas the vasodilator responses to nitroglycerin (NTG) were not affected.
The results indicate that supplemental oral vitamin C ´-nproved endotheliumdependent vasomotor dysfunction in smokers.
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